Pharmaceutical Development Breathing Simulator with Human Lung Environmental Simulation
The simulator system is in two parts. When used together it is designed to completely simulate the environmental conditions present inside a human lung.
An inhalation can be recorded in the field on a Si-Plan profile recorder and replayed on the electronic lung so that different drug doses, breathing rates or other environmental factors can be tested. The contents of the lung (suspended particles) are drawn through a partical sizer, typically and NGI device.
The cabinet on the left houses:
- ‘625’ breathing simulator
- Electronics control cabinet
- Facility to heat the breathed air to 37ºC (body temperature) and develop 100% relative humidity.
The apparatus on the right of the picture, also designed and built by Si-Plan Electronics Research Ltd, incorporates
- Laser particle-size analyser (can be moved to three different locations and 2 orientations)
- Extended airway which can accommodate an oropharyngeal cast
- Large chamber for particle settling prior to being evacuated through an impactor particle size analyser.
- Heated enclosures maintain the complete airway at elevated temperatures.